Animal Models of Neurological Disease, I: Neurodegenerative by Ernest D. Olfert (auth.), Alan A. Boulton, Glen B. Baker,

By Ernest D. Olfert (auth.), Alan A. Boulton, Glen B. Baker, Roger F. Butterworth (eds.)

to the Animal versions Volumes This and a number of other volumes within the Neuromethods sequence will describe a few animal types of neu- psychiatric issues. as a result of expanding public predicament over the moral therapy of animals in learn, we felt it incumbent upon us to incorporate this normal preface to those volumes that allows you to point out why we expect extra learn utilizing animals is critical and why animal types of psychi- ric and neurologic problems, particularly, are so vital. We realize that animals may still merely be used while appropriate possible choices are usually not to be had. we expect it self-e- dent, notwithstanding, that people can merely be experimented upon in critically proscribed conditions and substitute seasoned- dures utilizing phone or tissue tradition are insufficient in any types requiring exams of behavioral swap or of complicated in vivo techniques. although, while the misery, ache, or ache to the animals outweighs the expected earnings for human welfare, then the learn isn't really moral and shouldn't be carried out.

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Canadian Council on Animal Care (1985) Syllabus of The Basic Principles of Luborato y Animal Science. CCAC, Ottawa, Ontario. Canadian Council on Animal Care (July 1989) Categories of invasiveness in Animal Experiments. CCAC, Ottawa, 2pp. Canadian Council on Animal Care (June 1989) Ethics ofAnimal Experimentation. CCAC, Ottawa, 2 pp. Casey K. L. and Dubner R. (1989) Animal models of chronic pain: Scientific and ethical issues. Pain 38,249-252. Dawkins M. S. (1980) Animal Suffering-The Science of Animal Welfare.

The investigator or licensee must demonstrate that a search for alternatives has been adequately done. What form of assurance will be acceptable is still open to discussion. Some institutional animal care and use committees may accept a statement on their protocol forms signed by the investigator, that such a search has been done, and that the use of live animals in the study is necessary. There is no question that greater emphasis will be placed on this in the future when protocols are reviewed.

And Griffiths I’. H. M. (1985) Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment. Vet. 116,431-436. Orlans F. , Simmonds R. , and Dodds W. J. ) (1987) Special IssueEffective Animal Care and Use Committees. Lab. Anim. 37. Regan T. (1983) The Casefor Animal Rights. University of California Press, Berkeley. Rollin 8. E. (1981) Animal Rights and Human Morality. Prometheus Books, Buffalo, New York, pp. 89-148. Rollin B. E. (1985) The Moral Status of Research Animals in Psychology.

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