Autoantibodies in Neurological Diseases by G. Martino, A. Vincent (auth.), Angela Vincent, Gianvito

By G. Martino, A. Vincent (auth.), Angela Vincent, Gianvito Martino (eds.)

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Transplantation 49:317-321 42. Wagoner LE, Taylor DO, Olsen SL et al (1993) Immunosuppressive therapy, management, and outcome of heart transplant recipients during pregnancy. J Heart Lung Transplant 12:993-999 Pregnancy and Myasthenia Gravis 39 43. Jain A, Venkataramanan R, Fung JJ et al (1997) Pregnancy after liver transplantation under tacrolimus. Transplantation 64:559-565 44. Ramsey-Goldman R, Mientus JM, Kutzer JE et al (1993) Pregnancy outcome in women with systemic lupus erythematosus treated with immunosuppressive drugs.

Although some clinicians [54] recommend that azathioprine and cyclosporine should always be withdrawn in pregnancy, in our opinion, drugs can be continued throughout pregnancy to avoid life-threatening exacerbation if they play an important role in controlling the disease. However, the final decision on stopping or continuing to take the drug should be taken by the women concerned. Plasmapheresis [21,55] and high-dose gammaglobulins [21,56] are effective and safe treatments for myasthenic crises also in pregnancy.

Autoimmunity 12:315-316 58. Osserman KE, Kornfild P, Cohen E et al (1958) Studies in myasthenia gravis. AMA Arch Intern Med 102:72-81 Chapter 3 Immunological Mechanisms in the Lambert-Eaton Myasthenic Syndrome A. A. TONAL! The Lambert-Eaton myasthenic syndrome (LEMS) is an antibody-mediated disorder of neuromuscular and autonomic synaptic transmission. It is paraneoplastic in about 50% of cases, generally being associated with small-cell lung carcinoma (SCLC). In non-cancer cases, it can be associated with other autoimmune diseases [1].

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