Biochemical Approaches to Aging by Morton Rothstein

By Morton Rothstein

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W. (1971). Exp. Gerontol. 6, 49-56. Chapter 3 Free Radicals, Age Pigments, and Lipid Metabolism I. OVERVIEW The idea that cellular aging is related to damage of biological structures caused by free radicals holds a number of attractions. In particular, free radical attack can be related to several concepts that have been put forth as causes of aging in their own right. For example, to the extent that it exceeds repair capability, cross-linking resulting from free radical reactions could cause irreversible and cumulative damage to the genetic apparatus, leading to " e r r o r s " which might become amplified, or to omissions in information molecules.

In "The Biology of Aging" (C. E. Finch, L. ), pp. 159-186. Van Nostrand Reinhold, Princeton, New Jersey. Hayflick, L. (1979). /. Invest. Dermatol. 73, 8 - 1 4 . Hayflick, L. (1980). Mech. Ageing Dev. 14, 5 9 - 7 9 . Hayflick, L. and Moorhead, P. S. (1961). Exp. Cell Res. 25, 5 8 5 - 6 2 1 . , and Breuninger, V. (1979). Mech. Ageing Dev. 10, 1 1 7 - 1 3 0 . Hieb, W. , and Rothstein, M. (1975). Exp. Gerontol. 10, 145-153. Hoffman, H. J. (1978). In "Development of the Rodent as a Model System of Aging" (Gibson, D.

Lab. Animal Sci. 26, 3 2 0 - 3 2 8 . , Huschtscha, L. , Tarrant, and Kirkwood, Τ. B. L. (1977). Science 198, 366-372. , Russfield, A. , Weisburger, J. , Chak, S. , and Weisburger, Ε. K. (1975). /. Natl. Cancer Inst. 55, 3 7 - 4 5 . Honda, S„ and Matsuo, M. (1980). Mech. Ageing Dev. 12, 3 1 - 3 7 . Hosono, R. (1978). Exp. Gerontol. 13, 3 6 9 - 3 7 4 . , Aizawa, S. , and Mitsui, Y. (1980). Exp. Gerontol. 15, 2 8 5 - 2 8 9 . Hughes, R. , and Ayad, S. J. (1980). Biochem. Biophys. Acta 623, 2 0 2 - 2 0 9 .

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