Caffeine Blues: Wake Up to the Hidden Dangers of America's by Stephen Cherniske

By Stephen Cherniske

Pulls jointly all of the most recent examine & info the total scope of caffeine's dangerous impression on our actual, psychological & emotional health.

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B. and Sung, B. (2009b) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 30: 85-94. Alonso, A. and Hernan, M. A. (2008) Temporal trends in the incidence of multiple sclerosis: a systematic review. Neurology 71: 129-135. Ammon, H. , and Sabieraj, J. (1993) Mechanism of antiinflammatory actions of curcumine and boswellic acids. J. Ethnopharmacol. 38: 113-119. , Kunnumakkara, A. , Newman, R. , and Aggarwal, B. B. (2007) Bioavailability of curcumin: problems and promises.

Protein products of the ING genes have been shown to interact with p53 to collectively contribute to tumour suppression. Experiments using p53-transfected cells have demonstrated that that curcumin selectively increases p53 at the G2 phase of carcinoma cells. Although curcumin has been shown to upregulate p53 in a time dependent manner, the mechanism by which curcumin mediates p53 activity is still under investigation. Cell Survival and Proliferation Curcumin has also been shown to effectively suppress phosphorylated Akt (P-Akt), and vascular endothelial growth factor (VEGF) which contribute to the survival and proliferation of brain tumour cells(Purkayastha et al.

41: 40-59. Aggarwal, B. B. and Shishodia, S. (2004) Suppression of the nuclear factor-kappaB activation pathway by spice-derived phytochemicals: reasoning for seasoning. Ann. N Y Acad. Sci. 1030: 434-441. Aggarwal, B. B. and Sung, B. (2009b) Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 30: 85-94. Alonso, A. and Hernan, M. A. (2008) Temporal trends in the incidence of multiple sclerosis: a systematic review. Neurology 71: 129-135.

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