By John L. Wallace (auth.), Timothy S. Gaginella, Antonio Guglietta (eds.)
Drug improvement: Molecular ambitions for Gastrointestinal sickness brings jointly a panel of wonderful specialists to seriously assessment the various promising new parts of gastrointestinal pharmacology on the molecular point. Key chapters talk about such significant subject matters because the cyclooxygenase-2 inhibitors, the complexities of nitric oxide pathways within the intestine, and the impression of cytokines on inflammatory bowel illness, in addition to new possibilities for pharmacotherapy, together with peptide development components, tachykinins-particularly substance P and neurokinins-cholecystokinin receptors, and serotonin. additionally tested as attainable websites for treating motility problems and visceral soreness are the opioid receptors living within the intestine, and the H3-receptor agonists for treating intestine irritation and discomfort. Drug improvement: Molecular ambitions for Gastrointestinal ailment offers a finished evaluate of latest molecular pharmacological techniques to the invention and improvement of novel medications for gastrointestinal and liver ailments. Its broad references, richly skilled members, and state of the art syntheses of earlier, current, and emergent examine determine the ebook as a necessary source for all pharmacologists, medicinal chemists, and clinicians looking extra strong medicines for the prevention and remedy of gastrointestinal issues.