By Paul E. Perry (auth.), Frederick J. de Serres, Alexander Hollaender (eds.)
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Extra resources for Chemical Mutagens: Principles and Methods for Their Detection Volume 6
Palitti and A. Becchetti, Effect of caffeine on sister chromatid exchanges and chromosomal aberrations induced by mutag;ens in Chinese hamster cells, Mutat. Res. 45, 157~159 (1977). 66. T. M. Schroeder, Sister chromatid exchanges and chromatid interchanges in Bloom's syndrome, Humangenellk 30,317-323 (1975). 67. Y. Shiraishi and A. A. Sandberg, The relationship between sister chromatid exchanges and chromosome aberrations in Bloom's syndrome, Cytogenet. Cell Genet. 78, 13~23 (1977). 68. S. J. Bodycote, The induction of chromatid deletions in accord with the breakageand-reunion hypothesis, Mutat.
The amount of substitution may be further improved by injection of fluorodeoxyuridine several hours before BrdUrd administration to depress the activity of the enzyme thymidylate synthetase. Although it has been said that the toxic effects of BrdUrd can be suppressed by simultaneous treatment with deoxycytidine, (115 I recent work 1951 suggests that this is due simply to reduced BrdUrd incorporation. BrdUrd labeling in vivo was first demonstrated by Bloom and HSU,I381 who observed SCE in chick cells labeled in ova.
Obe, Frequency and distribution of sisterchromatid exchanges in a case of Fanconi's anemia, Humangenetik 27,227-230 (1975). 46. s. Wolff. 1. Bodycote, G. H. 1. E. l87. 349-355 (1975). 47. Y. Shiraishi. A. I. Freeman, and A. A. Sandberg, Increased sister chromatid exchange in bone marrow and blood cells from Bloom's syndrome, Cytogenet. Cell Genet. 77, 162-173 (1976). 48. E. A. Lezana, N. 0 Bianchi, M. S. Bianchi, and J. E. Zabala-Suarez, Sister chromatid exchanges in Down syndromes and normal human beings, Mutat.