Concepts and Case Studies in Chemical Biology by Herbert Waldmann, Petra Janning

By Herbert Waldmann, Petra Janning

Holding the confirmed didactic thought of the profitable "Chemical Biology - studying via Case Studies", this sequel positive aspects 27 new case reviews, reflecting the fast progress during this interdisciplinary subject over the last few years.
Edited via of the world's prime researchers within the box, this textbook introduces scholars and researchers to the trendy techniques in chemical biology, in addition to very important effects, and the concepts and strategies utilized. each one bankruptcy offers a distinct organic challenge taken from daily lab paintings, elucidated through a world workforce of well known scientists.
With its large insurance, this can be a worthwhile resource of data for college students, graduate scholars, and researchers engaged on the borderline among chemistry, biology, and biochemistry.

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12. 13. 14. 15. 16. 17. 18. (1989) Fluorescent indicators for cytosolic calcium based on rhodamine and fluorescein chromophores. J. Biol. , 264, 8171–8178. S. (2002) Design and synthesis of a fluorescent reporter of protein kinase activity. J. Am. Chem. , 124, 3840–3841. , and Imperiali, B. (2001) Derivatives of 8hydroxy-2-methylquinoline are powerful prototypes for zinc sensors in biological systems. J. Am. Chem. , 123, 5160–5161. , and Imperiali, B. (2003) Modular and tunable chemosensor scaffold for divalent zinc.

Accurate and physiologically relevant methods to quantify kinase activities are needed to understand the intricate dynamics of kinase activation and inactivation. This chapter describes the design, evolution, and application of fluorescent-based Ser/Thr/Tyr kinase activity sensors that take advantage of chelation-enhanced fluorescence (CHEF). These sensors are compatible with physiological conditions, are selective for specific protein kinases, and provide real-time kinetic information regarding kinase activity.

And Sudarsanam, S. (2002) The protein kinase complement of the human genome. Science, 298, 1912–1934. A. (2010) Kinase mutations in human disease: interpreting genotype-phenotype relationships. Nat. Rev. , 11, 60–74. Blume-Jensen, P. and Hunter, T. (2001) Oncogenic kinase signalling. Nature, 411, 355–365. , and Imperiali, B. (2005) Chemical approaches for investigating phosphorylation in signal transduction networks. , 15, 502–510. , and Chau, V. (1981) Fluorometric assay for adenosine 3′ ,5′ -cyclic monophosphate-dependent protein kinase and phosphoprotein phosphatase activities.

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